Literature summary for 1.6.5.2 extracted from

Gayam, S.R.; Venkatesan, P.; Sung, Y.M.; Sung, S.Y.; Hu, S.H.; Hsu, H.Y.; Wu, S.P.
An NAD(P)H quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo (2016), Nanoscale, 8, 12307-12317 .

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Protein Variants

Protein Variants	Comment	Organism
medicine	use of endogenous NQO1 enzyme for nanocarrier-based drug delivery in tumors. The rotaxane nanovalve system is composed of a linear stalk anchoring on the surface of mesoporous silica nanoparticles, an alpha-cyclodextrin ring that encircles it and locks the payload cargo molecules in the mesopores, and a benzoquinone stopper incorporated at the end of the stalk. The gate opening and controlled release of the cargo are triggered by cleavage of the benzoquinone stopper using an endogenous NQO1 enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HL-60 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)