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Literature summary for 1.6.5.2 extracted from
- Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H quinone oxidoreductase 1 in Hepa1c1c7 cells (2017), Fitoterapia, 119, 115-120 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q64669 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hepa-1c1c7 cell | - |
Mus musculus | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | after 48 h of exposure, 2,3-dehydrosilydianin at concentrations of 25 microM and higher significantly elevates the activity of NQO1 in murine hepatoma Hepa1c1c7 cells. 2,3-dehydrosilydianin causes the accumulation of Nrf2 and significantly induces the expression of the Nqo1 gene at both the mRNA and protein levels | up |
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