Crystallization (Comment) | Organism |
---|---|
structure of mutant P187S | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
P187S | naturally occurring single-nucleotide polymorphism implicated in the development of various cancers. Crystal structure is almost identcal to wild-type, the amino acid exchange destabilizes interactions between the core and C-terminus, leading to depopulation of the native structure in solution and severely compromising the catalytic capacity of the variant protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15559 | - |
- |