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BRENDA support

Literature summary for 1.6.5.2 extracted from

  • Lienhart, W.D.; Gudipati, V.; Uhl, M.K.; Binter, A.; Pulido, S.A.; Saf, R.; Zangger, K.; Gruber, K.; Macheroux, P.
    Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H quinone oxidoreductase (2014), FEBS J., 281, 4691-4704 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of mutant P187S Homo sapiens

Protein Variants

Protein Variants Comment Organism
P187S naturally occurring single-nucleotide polymorphism implicated in the development of various cancers. Crystal structure is almost identcal to wild-type, the amino acid exchange destabilizes interactions between the core and C-terminus, leading to depopulation of the native structure in solution and severely compromising the catalytic capacity of the variant protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15559
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