Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64669 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | leflunomide elicites significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
NQO1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | leflunomide elicits significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice. The dose at which leflunomide increases NQO1 is significantly higher than that required to induce CYP1A1 enzyme. Leflunomide also enhances hepatic CYP1A1, 1A2 and NQO1 expression in wild-type mice and fails to induce these enzymes in aryl hydrocarbon receptor-null mice | up |