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Literature summary for 1.6.5.2 extracted from

  • Nam, S.T.; Hwang, J.H.; Kim, D.H.; Park, M.J.; Lee, I.H.; Nam, H.J.; Kang, J.K.; Kim, S.K.; Hwang, J.S.; Chung, H.K.; Shong, M.; Lee, C.H.; Kim, H.
    Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells (2014), BMB Rep., 47, 494-499.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine isoform NQO1-KO mice exhibit a marked increase of permeability and spontaneous inflammation in the gut. In the dextran sulfate sodium salt-induced colitis model, NQO1-KO mice show more severe inflammatory responses than NQO1-wild-type mice. The transcript levels of claudin and occludin, the major tight junction molecules of gut epithelial cells, are significantly decreased in NQO1-KO mice. The colons of NQO1-KO mice also show high levels of reactive oxygen species and histone deacetylase activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q64669
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-

Source Tissue

Source Tissue Comment Organism Textmining
colon
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 Mus musculus
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intestine
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 Mus musculus
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Synonyms

Synonyms Comment Organism
NADH:quinone oxidoreductase 1
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 Mus musculus
NQO1
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 Mus musculus

General Information

General Information Comment Organism
physiological function isoform NQO1-KO mice exhibit a marked increase of permeability and spontaneous inflammation in the gut. In the dextran sulfate sodium salt-induced colitis model, NQO1-KO mice show more severe inflammatory responses than NQO1-wild-type mice. The transcript levels of claudin and occludin, the major tight junction molecules of gut epithelial cells, are significantly decreased in NQO1-KO mice. The colons of NQO1-KO mice also show high levels of reactive oxygen species and histone deacetylase activity Mus musculus