Literature summary for 1.6.5.2 extracted from

Stiborova�, M.; Dracinska�, H.; Marti�nek, V.; Svaskova�, D.; Hodek, P.; Milichovsky, J.; Hejdukova�, Z.; Brotanek, J.; Schmeiser, H.; Frei, E.
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I) (2013), Chem. Res. Toxicol., 26, 290-299.

Search for more literature for 1.6.5.2

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
microsome	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADH + H+ + 2-methyl-1,4-naphthoquinone	Rattus norvegicus	-	NAD+ + 2-methyl-1,4-naphthoquinol	-	?
NADPH + H+ + 2-methyl-1,4-naphthoquinone	Rattus norvegicus	-	NADP+ + 2-methyl-1,4-naphthoquinol	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + H+ + 2-methyl-1,4-naphthoquinone	-	Rattus norvegicus	NAD+ + 2-methyl-1,4-naphthoquinol	-	?
NADPH + H+ + 2-methyl-1,4-naphthoquinone	-	Rattus norvegicus	NADP+ + 2-methyl-1,4-naphthoquinol	-	?

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone oxidoreductase 1	-	Rattus norvegicus
NQO1	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Rattus norvegicus
NADPH	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	Sudan I induces NQO1 expression in rat liver, kidney, and lung, real-time polymerase chain reaction expression analysis	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)