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Literature summary for 1.6.5.2 extracted from
- Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase (2007), Z. Naturforsch. C, 61, 889-895.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| desferrioxamine | stimulates the NADPH:chromate reductase reaction of NQO1 | Rattus norvegicus |  |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | oxidative stress-type cytotoxicity of chromate in FLK cells may be partly attributed to its reduction by NQO1, but not by glutathione reductase | Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dicumarol | inhibits the reduction of chromate by the digiton-permeabilized FLK cells in the presence of NADPH regeneration system. Protects against cytotoxicity by inhibiting NQO1 | Ovis aries | |
| SOD | inhibits the NADPH:chromate reductase reaction of NQO1 | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| FLK cell | - |
Ovis aries | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chromate(VI) + H2O | - |
Ovis aries | chromate(III) + H2O2 | - |
? | |
| chromate(VI) + H2O | extremely poor substrate | Rattus norvegicus | chromate(III) + H2O2 | - |
? | |
| menadione + NADPH | - |
Rattus norvegicus | reduced menadione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DT-diaphorase | - |
Rattus norvegicus |
| DT-diaphorase | - |
Ovis aries |
| EC 1.6.99.2 | formerly | Rattus norvegicus |
| EC 1.6.99.2 | formerly | Ovis aries |
| NAD(P)H:quinone oxidoreductase | - |
Rattus norvegicus |
| NAD(P)H:quinone oxidoreductase | - |
Ovis aries |
| NQO1 | - |
Rattus norvegicus |
| NQO1 | - |
Ovis aries |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
menadione | at pH 7.0 and 27°C | Rattus norvegicus | |
| 1.8 | - |
chromate(VI) | at pH 7.0 and 27°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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