Literature summary for 1.6.5.2 extracted from

Sripathy, S.P.; Chaplin, L.J.; Gaikwad, N.W.; Rogan, E.G.; Montano, M.M.
hPMC2 is required for recruiting an ERbeta coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen (2008), Oncogene, 27, 6376-6384.

Search for more literature for 1.6.5.2

Application

Application	Comment	Organism
additional information	ERbeta and hPMC2 are required for trans-hydroxytamoxifen-dependent recruitment of coactivators such as PARP-1 to the electrophile response element of NQO1 resulting in the induction of the antioxidative enzyme and subsequent protection against oxidative DNA damage	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-10A cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NQO1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
additional information	trans-hydroxytamoxifen-dependent recruitment of coactivators ERbeta and hPMC2 to the electrophile response element sequence of NQO1. Trans-hydroxytamoxifen-dependent corecruitment of the coactivators Nrf2, PARP-1 and topoisomerase IIbeta, both in the presence and absence of ERalpha. Absence of either ERbeta or hPMC2 results in nonrecruitment of PARP-1 and topoisomerase IIbeta, loss of antioxidative enzyme induction and attenuated protection against oxidative DNA damage by trans-hydroxytamoxifen even in the presence of Nrf2 and ERalpha	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)