Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | irradiation with 4 Gy causes a long-lasting upregulation of NQO1, thereby increasing NQO1-mediated beta-lap-induced cell deaths | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | NQO1-induced bioreduction of beta-lap is an essential step in beta-lap-induced cell death. Combined radiotherapy and beta-lap treatment can have a significant effect on human tumor xenografts | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | inhibitor of NQO1, inhibits clonogenic cell death caused by beta-lap | Homo sapiens | |
siRNA | siRNA for NQO1 inhibits clonogenic cell death caused by beta-lap | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
additional information | lung epithelial cancer cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytochrome C + menadione + NADH | - |
Homo sapiens | ? + reduced menadione + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |