Literature summary for 1.6.5.2 extracted from

Zhang, W.; Go, M.L.
Quinone reductase induction activity of methoxylated analogues of resveratrol (2007), Eur. J. Med. Chem., 42, 841-850.

Search for more literature for 1.6.5.2

Activating Compound

Activating Compound	Comment	Organism	Structure
1,1'-(E)-ethene-1,2-diylbis(2-methoxybenzene)	at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol	Mus musculus
1,3-dimethoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene	at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol	Mus musculus
1-methoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene	at 6.3 micromol is 1.8 times more effective than resveratrol as a quinone reductase inducer	Mus musculus
1-methoxy-3-[(E)-2-(4-methoxyphenyl)ethenyl]benzene	at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol	Mus musculus
2-methoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenol	at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol	Mus musculus
additional information	compared to resveratrol, analogues with ortho-methoxy substituents are more potent inducers of quinone reductase and exert their activity in a qualitatively different manner	Mus musculus
resveratrol	at 25 micromol increases quinone reductase activity by 1.5fold. Resveratrol induces quinone reductase activity of the wild type Hepa-1c1c7 cells to the same extent as the mutant c1 cells that lack a phase I enzyme	Mus musculus

Application

Application	Comment	Organism
drug development	greater induction activities of the phase II enzyme quinone reductase associated with stilbenoids serve as a useful starting point for the design of improved chemopreventive agents	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hepa-1c1c7 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone reductase	-	Mus musculus
Quinone reductase	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)