Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ES 936 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme, stably transfected to breast cancer cell line MDA468 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-(2-dimethylylamino)ethylamino-17-demethoxygeldanamycin + NAD(P)H + H+ | - |
Homo sapiens | reduced 17-(2-dimethylylamino)ethylamino-17-demethoxygeldanamycin + NADP+ | reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin | ? | |
17-(2-pyrrolidin-1-yl)ethylamino-17-demethoxygeldanamycin + NAD(P)H + H+ | - |
Homo sapiens | reduced 17-(2-pyrrolidin-1-yl)ethylamino-17-demethoxygeldanamycin + NADP+ | reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin | ? | |
17-allylamino-17-demethoxygeldanamycin + NAD(P)H + H+ | - |
Homo sapiens | reduced 17-allylamino-17-demethoxygeldanamycin + NADP+ | reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin | ? | |
17-amino-17-demethoxygeldanamycin + NAD(P)H + H+ | - |
Homo sapiens | reduced 17-amino-17-demethoxygeldanamycin + NADP+ | reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin | ? | |
geldanamycin + NAD(P)H + H+ | - |
Homo sapiens | reduced geldanamycin + NADP+ | reduced component is a more potent Hsp90 inhibitor than parent benzoquinone ansamycin | ? |