Literature summary for 1.6.5.2 extracted from

Han, E.H.; Hwang, Y.P.; Jeong, T.C.; Lee, S.S.; Shin, J.G.; Jeong, H.G.
Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase (2007), FEBS Lett., 581, 749-756.

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Activating Compound

Activating Compound	Comment	Organism	Structure
eugenol	increases expression and activity of enzyme by NF-E2 related factor2 binding to antioxidant response element in enzyme gene	Homo sapiens
eugenol	increases the expression and activity of NAD(P)H:quinone oxidoreductase through NF-E2 related factor2 binding to antioxidant response element in QR gene in a dose-dependent manner	Homo sapiens

Application

Application	Comment	Organism
drug development	NAD(P)H:quinone oxidoreductase is a major detoxifying enzyme for 7,12-dimethylbenz[a]anthracene. Eugenol has a potent protective effect against 7,12-dimethylbenz[a]anthracene-induced genotoxicity, presumably through the suppression of the 7,12-dimethylbenz[a]anthracene activation and the induction of its detoxification through NAD(P)H:quinone oxidoreductase	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
QR-ARE-luciferase reporter plasmid expressed in MCF-7 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
menadione + NADH	-	Homo sapiens	reduced menadione + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone oxidoreductase	-	Homo sapiens

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Release 2023.1 (January 2023)