Literature summary for 1.6.5.2 extracted from

Asher, G.; Dym, O.; Tsvetkov, P.; Adler, J.; Shaul, Y.
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol (2006), Biochemistry, 45, 6372-6378.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor dicoumarol	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
dicoumarol	binding of dicoumarol induces conformational changes involving Y128 and F232 on the surface of enzyme catalytic pocket	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone	specific conformations of Y128 and F232 on the surface of the catalytic pocket are important for interaction of enzyme with p53 and other client proteins	Homo sapiens	a

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Release 2023.1 (January 2023)