Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the main cytotoxicity mechanism of antitumour aziridinyl-benzoquinones is their two-electron reduction to alkylating products by NAD(P)H:quinone oxidoreductase. In addition to the activation of NQO1 the oxidative stress, presumably initiated by single-electron enzymatic reduction, plays an important role in the cytotoxicity of aziridinyl-substituted quinones | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,4-naphthoquinone + NADPH + H+ | - |
Rattus norvegicus | 1,4-naphthosemiquinone + NADP+ | - |
? | |
1,4-naphthoquinone + NADPH + H+ | - |
Rattus norvegicus | 1,4-naphthoquinol + NADP+ | - |
? | |
1,8-dihydroxy-9,10-anthraquinone + NADPH | - |
Rattus norvegicus | 1,8-dihydroxy-9,10-anthraquinol + NADP+ | - |
? | |
2,5-bis(ethylamine)-3,6-diaziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-bis(ethylamine)-3,6-diaziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2,5-diaziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-diaziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinol + NADP+ | - |
? | |
2,5-dimethyl-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2,5-dimethyl-1,4-naphthoquinol + NADP+ | - |
? | |
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
2-methyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-1,4-benzoquinol + NADP+ | - |
? | |
2-methyl-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-1,4-naphthoquinol + NADp+ | - |
? | |
2-methyl-5-aziridinyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-5-aziridinyl-1,4-benzoquinol + NADP+ | - |
? | |
2-methyl-5-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 2-methyl-5-hydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
5,8-dihydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 5,8-dihydroxy-1,4-naphthoquinol + NADP+ | - |
? | |
5-hydroxy-1,4-naphthoquinone + NADPH | - |
Rattus norvegicus | 5-hydroxy-1,4-naphthosemiquinone + NADP+ | - |
? | |
9,10-phenanthrene quinone + NADPH | - |
Rattus norvegicus | 9,10-phenanthrene quinol + NADP+ | - |
? | |
additional information | the main cytotoxicity mechanism of antitumour aziridinyl-benzoquinones is their two-electron reduction to alkylating products by NAD(P)H:quinone oxidoreductase. In addition to the activation of NQO1 the oxidative stress, presumably initiated by single-electron enzymatic reduction, plays an important role in the cytotoxicity of aziridinyl-substituted quinones | Rattus norvegicus | ? | - |
? | |
tetramethyl-1,4-benzoquinone + NADPH | - |
Rattus norvegicus | tetramethyl-1,4-benzoquinol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH:quinone oxidoreductase | - |
Rattus norvegicus |
NQO1 | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
1,8-dihydroxy-9,10-anthraquinone | pH 7.0, 25°C | Rattus norvegicus | |
40 | - |
2,5-bis(ethylamine)-3,6-diaziridinyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
52 | - |
9,10-phenanthrene quinone | pH 7.0, 25°C | Rattus norvegicus | |
71 | - |
5,8-Dihydroxy-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
111 | - |
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
232 | - |
2-Hydroxy-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
242 | - |
5-hydroxy-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
287 | - |
2-methyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
380 | - |
2-methyl-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
431 | - |
1,4-Naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
500 | - |
2-methyl-5-hydroxy-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
500 | - |
2,5-dimethyl-1,4-naphthoquinone | pH 7.0, 25°C | Rattus norvegicus | |
1000 | - |
tetramethyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
1540 | - |
2-methyl-5-aziridinyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
1550 | - |
2,5-diaziridinyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus | |
2000 | - |
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | pH 7.0, 25°C | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |