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Literature summary for 1.6.5.2 extracted from

  • Giuditta, A.; Strecker, H.J.
    Purification and some properties of a brain diaphorase (1961), Biochim. Biophys. Acta, 48, 10-19.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Bos taurus
2,4-dinitrophenol 0.067 mM, 56% inhibition Bos taurus
3,3'-methylene-bis(4-hydroxycoumarin) 0.000033 mM, 56% inhibition Bos taurus
4-hydroxymercuribenzoate 0.067 mM, 50% inhibition Bos taurus
Amytal 6.6 mM, 55% inhibition Bos taurus
N-ethyl maleimide 0.33 mM, complete inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
menadione cofactor NADH Bos taurus
0.024
-
methylene blue cofactor NADPH Bos taurus
0.04
-
menadione cofactor NADPH Bos taurus
0.3
-
vitamin K1 cofactor NADPH Bos taurus
0.33
-
vitamin K1 cofactor NADH Bos taurus
1.4
-
potassium ferricyanide cofactor NADPH Bos taurus
1.7
-
potassium ferricyanide cofactor NADH Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
230000.0 units/mg, 1 unit is defined as the amount of enzyme causing a decrease in absorbance at 340 nm of 0.001/min Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-1,4-naphthoquinone + NAD(P)H artificial acceptor, trivial name menadione Bos taurus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
?
2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H
-
Bos taurus 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+
-
?
K3[Fe(CN)6] + NAD(P)H no activity with coenzyme Q10 Bos taurus K4[Fe(CN)6] + NAD(P)+
-
?
K3[Fe(CN)6] + NAD(P)H no activity with lipoic acid, cytochrome c and vitamin K1 Bos taurus K4[Fe(CN)6] + NAD(P)+
-
?
methylene blue + NAD(P)H
-
Bos taurus reduced methylene blue + NAD(P)+
-
?
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
Bos taurus NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
?
potassiumferricyanide + NADH + H+
-
Bos taurus potassium ferrocyanide + NAD+
-
r
potassiumferricyanide + NADPH + H+
-
Bos taurus potassium ferrocyanide + NADP+
-
r

Cofactor

Cofactor Comment Organism Structure
FAD stimulates Bos taurus
FAD enzyme contains FAD Bos taurus
FMN stimulation Bos taurus
NAD+
-
Bos taurus
NADP+
-
Bos taurus