Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | palmitic acid and antimycin A induce the enzyme and superoxide production | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenylene iodonium | inhibition of the NADPH oxidase complex activity reduces the increase of superoxide production induced by palmitic acid | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | NADPH oxidase complex consists of membrane and cytosolic subunits | Rattus norvegicus | 5737 | - |
membrane | NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme | Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + cytochrome c | Rattus norvegicus | - |
NADP+ + reduced cytochrome c | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle cell | soleus, gastrocnemius, and quadriceps muscles, primary culture of cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + cytochrome c | - |
Rattus norvegicus | NADP+ + reduced cytochrome c | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
NADPH oxidase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b558 | gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme | Rattus norvegicus | |
cytochrome c | - |
Rattus norvegicus |