Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.3.4 extracted from

  • Yamamoto, Y.; Pargade, V.; Lamberet, G.; Gaudu, P.; Thomas, F.; Texereau, J.; Gruss, A.; Trieu-Cuot, P.; Poyart, C.
    The Group B Streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulence (2006), Mol. Microbiol., 62, 772-785.
    View publication on PubMed
Search for more literature for 1.6.3.4

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptococcus agalactiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Streptococcus agalactiae 5737
-

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae Q8E5N5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 NADH + H+ + O2
-
 Streptococcus agalactiae NAD+ + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
Nox-2
-
 Streptococcus agalactiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Streptococcus agalactiae

General Information

General Information Comment Organism
malfunction the inability of the nox2 mutant to grow aerobically is mainly due to an underlying defect in fatty acid biosynthesis. NAD+ depletion in the nox2 mutant results in reduced acetyl-CoA production, which perturbs fatty acid biosynthesis and hence blocks growth in aerobiosis Streptococcus agalactiae
physiological function the enzyme is essential for aerobic growth and oxidative stress resistance in conventional culture media. The enzyme facilitates adaptation of group B Streptococci to aerobic conditions encountered during infection Streptococcus agalactiae