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Literature summary for 1.6.3.1 extracted from

  • Ameziane-El-Hassani, R.; Talbot, M.; de Souza Dos Santos, M.C.; Al Ghuzlan, A.; Hartl, D.; Bidart, J.M.; De Deken, X.; Miot, F.; Diallo, I.; de Vathaire, F.; Schlumberger, M.; Dupuy, C.
    NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation (2015), Proc. Natl. Acad. Sci. USA, 112, 5051-5056 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Homo sapiens
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Homo sapiens NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
Duox1
-
 Homo sapiens
NADPH oxidase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is elevated in human radio-induced thyroid tumors and in sporadic thyroid tumors up

General Information

General Information Comment Organism
physiological function the enzyme promotes long-term persistence of oxidative stress after an exposure to irradiation. Enzyme-dependent H2O2 production, which induces DNA double-strand breaks, can cause genomic instability and promote the generation of neoplastic cells through its mutagenic effect Homo sapiens