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Literature summary for 1.6.3.1 extracted from

  • De Blasio, M.J.; Ramalingam, A.; Cao, A.H.; Prakoso, D.; Ye, J.M.; Pickering, R.; Watson, A.M.D.; de Haan, J.B.; Kaye, D.M.; Ritchie, R.H.
    The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy (2017), Eur. J. Pharmacol., 807, 12-20 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Rattus norvegicus
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Rattus norvegicus NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
 Rattus norvegicus
Nox2 isoform Rattus norvegicus
Nox4 isoform Rattus norvegicus
p47phox isoform Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus enzyme expression is upregulated in diabetes up