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Literature summary for 1.6.3.1 extracted from

  • Harnvoravongchai, P.; Kobori, H.; Orita, I.; Nakamura, S.; Imanaka, T.; Fukui, T.
    Characterization and gene deletion analysis of four homologues of group 3 pyridine nucleotide disulfide oxidoreductases from Thermococcus kodakarensis (2014), Extremophiles, 18, 603-616.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Thermococcus kodakarensis

Inhibitors

Inhibitors Comment Organism Structure
CoA NADH-dependent oxidase activities is strongly inhibited by addition of free CoA, whereas NADPH dependent activity is not; NADH-dependent oxidase activities is strongly inhibited by addition of free CoA, whereas NADPH dependent activity is not; NADH-dependent oxidase activities is strongly inhibited by addition of free CoA, whereas NADPH dependent activity is not; NADH-dependent oxidase activities is strongly inhibited by addition of free CoA, whereas NADPH dependent activity is not Thermococcus kodakarensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
2 * 40000, SDS-PAGE Thermococcus kodakarensis
49000
-
2 * 49000, SDS-PAGE Thermococcus kodakarensis
49000
-
4 * 49000, SDS-PAGE Thermococcus kodakarensis
50000
-
6 * 50000, SDS-PAGE Thermococcus kodakarensis
100000
-
-
Thermococcus kodakarensis
330000
-
gel filtration Thermococcus kodakarensis

Organism

Organism UniProt Comment Textmining
Thermococcus kodakarensis Q5JFZ8
-
-
Thermococcus kodakarensis Q5JGF8
-
-
Thermococcus kodakarensis Q5JGP4
-
-
Thermococcus kodakarensis Q5JHY2
-
-
Thermococcus kodakarensis Q5JJB9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Thermococcus kodakarensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + O2
-
Thermococcus kodakarensis NAD+ + H2O2
-
?
NADH + H+ + O2 activity with NADPH is much lower than with NADH Thermococcus kodakarensis NAD+ + H2O2
-
?
NADPH + H+ + O2
-
Thermococcus kodakarensis NADP+ + H2O2
-
?
NADPH + H+ + O2 activity with NADPH is much lower than with NADH Thermococcus kodakarensis NADP+ + H2O2
-
?

Subunits

Subunits Comment Organism
? 2 * 40000, SDS-PAGE Thermococcus kodakarensis
homodimer
-
Thermococcus kodakarensis
homodimer 2 * 49000, SDS-PAGE Thermococcus kodakarensis
homohexamer 6 * 50000, SDS-PAGE Thermococcus kodakarensis
homotetramer 4 * 49000, SDS-PAGE Thermococcus kodakarensis

Synonyms

Synonyms Comment Organism
NAD(P)H oxidase
-
Thermococcus kodakarensis
NOX
-
Thermococcus kodakarensis
TK0304 locus name Thermococcus kodakarensis
TK0828 locus name Thermococcus kodakarensis
TK1186 locus name Thermococcus kodakarensis
TK1299 locus name Thermococcus kodakarensis
TK1481 locus name Thermococcus kodakarensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
assay at Thermococcus kodakarensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Thermococcus kodakarensis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Thermococcus kodakarensis
NADH preference to NADPH versus NADH as an electron donor during oxygen reduction Thermococcus kodakarensis
NADPH
-
Thermococcus kodakarensis
NADPH preference to NADPH versus NADH as an electron donor during oxygen reduction Thermococcus kodakarensis