Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | depolarization of membrane potential of endothelial cells leads to activation of NAD(P)H oxidase and, consequently, superoxide anion production | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H oxidase | - |
Rattus norvegicus |
NADPHox | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | blockade of NAD(P)H oxidase with apocynin or superoxide dismutationwith PEG-SOD prevents the increment in superoxide and changes in P-eNOSThr495 observed during apamin and triarylmethane-34 application | Rattus norvegicus |
metabolism | mechanisms involved in the control of NO production involving the enzyme, NADPHox-mediated superoxide formation is involved in the inhibition of NO production, overview | Rattus norvegicus |
physiological function | blockade of small-conductance and intermediate-conductance Ca2+-activated K+ channels activates NAD(P)H oxidase-dependent superoxide formation, which leads to inhibition of NO release through P-eNOSThr495 | Rattus norvegicus |