Literature summary for 1.6.3.1 extracted from

Gaete, P.S.; Lillo, M.A.; Ardiles, N.M.; Perez, F.R.; Figueroa, X.F.
Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase (2012), Free Radic. Biol. Med., 52, 860-870.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	depolarization of membrane potential of endothelial cells leads to activation of NAD(P)H oxidase and, consequently, superoxide anion production	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-
Rattus norvegicus Sprague-Dawley	-	-	-

Synonyms

Synonyms	Comment	Organism
NAD(P)H oxidase	-	Rattus norvegicus
NADPHox	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	blockade of NAD(P)H oxidase with apocynin or superoxide dismutationwith PEG-SOD prevents the increment in superoxide and changes in P-eNOSThr495 observed during apamin and triarylmethane-34 application	Rattus norvegicus
metabolism	mechanisms involved in the control of NO production involving the enzyme, NADPHox-mediated superoxide formation is involved in the inhibition of NO production, overview	Rattus norvegicus
physiological function	blockade of small-conductance and intermediate-conductance Ca2+-activated K+ channels activates NAD(P)H oxidase-dependent superoxide formation, which leads to inhibition of NO release through P-eNOSThr495	Rattus norvegicus

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Release 2023.1 (January 2023)