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Literature summary for 1.6.3.1 extracted from

  • Kleinschnitz, C.; Grund, H.; Wingler, K.; Armitage, M.E.; Jones, E.; Mittal, M.; Barit, D.; Schwarz, T.; Geis, C.; Kraft, P.; et al
    Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration (2010), PLoS Biol., 8, e1000479.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Application

Application Comment Organism
medicine NADPH oxidase type 4 is a major source of oxidative stress and an effective therapeutic target in acute stroke Mus musculus
medicine NADPH oxidase type 4 is a major source of oxidative stress and an effective therapeutic target in acute stroke Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Mus musculus
-
 NADP+ + H2O2
-
 ?
NADPH + H+ + O2 Homo sapiens
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Mus musculus
-
blood vessel
-
 Homo sapiens
-
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
cerebrum
-
 Mus musculus
-
cerebrum
-
 Homo sapiens
-
endothelial cell
-
 Mus musculus
-
endothelial cell
-
 Homo sapiens
-
neuron
-
 Mus musculus
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Mus musculus NADP+ + H2O2
-
 ?
NADPH + H+ + O2
-
 Homo sapiens NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NADPH oxidase type 4
-
 Mus musculus
NADPH oxidase type 4
-
 Homo sapiens
Nox4
-
 Mus musculus
Nox4
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus expression of NOX4 mRNA is significantly higher 12 h and 24 h after transient middle cerebral artery occlusion in the basal ganglia and neocortex of wild type mice than in sham-operated controls up
Homo sapiens NOX4 gene expression is stronger in brain samples from stroke patients compared to healthy controls up

General Information

General Information Comment Organism
malfunction mice deficient in NOX4 of either sex, but not those deficient for NOX1 or NOX2, are largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after both transient and permanent cerebral ischemia Mus musculus