Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenyleneiodonium | NAD(P)H oxidase inhibitor, complete inhibition at 0.001 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glomerular endothelial cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Rattus norvegicus | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p47phox | NAD(P)H oxidase subunit | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
heme | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the level of p47phox protein, an NAD(P)H oxidase subunit, is increased by angiotensin II treatment (0.01 mM) with a peak being reached at 8 h. This increase is reduced by 0.001 mM diphenyleneiodonium and 0.001 mM telmisartan treatment | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the inhibition of NAD(P)H oxidase-dependent nuclear factor-kappa B signaling reduces the increase in monocyte chemoattractant protein-1 production by glomerular endothelial cells induced by angiotensin II | Rattus norvegicus |