Literature summary for 1.6.3.1 extracted from

Kim, Y.S.; Morgan, M.J.; Choksi, S.; Liu, Z.G.
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death (2007), Mol. Cell, 26, 675-687.

Search for more literature for 1.6.3.1

Activating Compound

Activating Compound	Comment	Organism	Structure
tumor necrosis factor	treatment of fibroblasts induces the formation of a signaling complex containing TNF-R1-associated death domain protein TRADD, receptor interacting protein RIP1, NAD(P)H oxidase Nox1, and the small GTPase Rac1. Formation of this complex plays a key role in tumor necrosis factor-induced necrotic cell death	Mus musculus

Application

Application	Comment	Organism
medicine	treatment of fibroblasts with tumor necrosis factor induces the formation of a signaling complex containing TNF-R1-associated death domain protein TRADD, receptor interacting protein RIP1, NAD(P)H oxidase Nox1, and the small GTPase Rac1. Formation of this complex plays a key role in tumor necrosis factor-induced necrotic cell death	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform Nox1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-

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Release 2023.1 (January 2023)