Literature summary for 1.6.3.1 extracted from

Ding, H.; Aljofan, M.; Triggle, C.R.
Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells (2007), J. Cell. Physiol., 212, 682-689.

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Activating Compound

Activating Compound	Comment	Organism	Structure
glucose	oxidative stress and expression of the NADPH oxidase subunit, p22phox, are both increased, superoxide dismutase 1 and 3 expression lowered and endothelial nitric oxide synthase significantly elevated in microvessel endothelial cells treated with 40mM glucose for 72 h compared to low glucose medium. Oxidative stress, p22phox mRNA, endothelial nitric oxide synthase mRNA, and protein are lowered by concurrent incubation with sepiapterin	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
sepiapterin	induction of oxidative stress, p22phox mRNA, endothelial nitric oxide synthase mRNA, and protein by glucose are lowered by concurrent incubation with sepiapterin	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	microvessel endothelial cell	Mus musculus	-

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Release 2023.1 (January 2023)