Literature summary for 1.6.3.1 extracted from

Ribe, D.; Sawbridge, D.; Thakur, S.; Hussey, M.; Ledent, C.; Kitchen, I.; Hourani, S.; Li, J.M.
Adenosine A2A receptor signaling regulation of cardiac NADPH oxidase activity (2008), Free Radic. Biol. Med., 44, 1433-1442.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	knockout of adenosine A2A receptor significantly decreases NADPH-dependent superoxide anion production in mouse hearts compared to age-matched wild-type controls, accompanied by a significant decrease in catalytic subunit Nox2 protein expression, and down-regulation of ERK1/2, p38MAPK, and JNK phosphorylation. In wild-type mice, intraperitoneal injection of the selective adenosine A2A receptor antagonist SCH58261 inhibits phosphorylation of regulatory subunit p47phox, which is accompanied by a down-regulated cardiac reactive oxygen species production, and decreased JNK and ERK1/2 activation	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	adenosine A2A receptor regulates subunit p47phox phosphorylation and cardiac reactive oxygen species production by NADPH oxidase through MAPK signaling	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

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Release 2023.1 (January 2023)