Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | presence of Candida albicans does not activate NADPH oxidase in dendritic cells | Homo sapiens | |
phorbol 12-myristate 13-acetate | stimualtion. Treated dendritic cells are are more competent in killing Candida albicans | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | NADPH oxidase is involved in killing of Candida albicans by dendritic cells, which is increased by interferon-alpha or interferon-gamma. However, Candida escapes the oxidative damage by inhibiting NADPH oxidase and by entering dendritic cells through receptors not involved in NADPH oxidase activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | presence of Candida albicans inhibits by contrasting the assembly of the enzyme on dedritic cell's plasma membrane | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | monocyte-dervide dendritic cell | Homo sapiens | - |