Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | exposure tolipopolysaccharide leads to the demise of motor neurons in a dose- and time-dependent manner, whereas interneurons are impaired relatively mildly. NADPH oxidase is activated upon lipopolysaccharide challenge, and inhibitor apocynin prevents inflammation-mediated toxicity to motor neurons | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | prevents inflammation-mediated toxicity to motor neurons induced by lipopolysaccharide | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
spinal cord | lumbal spinal cord slice | Rattus norvegicus | - |