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Literature summary for 1.6.3.1 extracted from

  • Sicard, P.; Acar, N.; Gregoire, S.; Lauzier, B.; Bron, A.M.; Creuzot-Garcher, C.; Bretillon, L.; Vergely, C.; Rochette, L.
    Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats (2007), Br. J. Pharmacol., 151, 979-986.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine rosuvastatin reduces systolic blood pressure in spontaneously hypertensive rats but does not change plasma lipid levels. Rosuvastatin treatment in spontaneously hypertensive rats significantly decreases reactive oxygen species levels , NAD(P)H activity in retinal ganglion cells, and increases retinal plasmalogen content in spontaneously hypertensive rats, but does not modify the electroretinogram response Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
rosuvastatin rosuvastatin reduces systolic blood pressure in spontaneously hypertensive rats but does not change plasma lipid levels. Rosuvastatin treatment in spontaneously hypertensive rats significantly decreases reactive oxygen species levels, NAD(P)H activity in retinal ganglion cells, and increases retinal plasmalogen content in spontaneously hypertensive rats, but does not modify the electroretinogram response Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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spontaneously hypertensive rats
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Source Tissue

Source Tissue Comment Organism Textmining
retina retinal ganglion cell reactive oxygen species and retinal NAD(P)H oxidase activity are higher in spontaneously hypertensive rats than in wild-type rats Rattus norvegicus
-