Activating Compound | Comment | Organism | Structure |
---|---|---|---|
transforming growth factor-beta | up-regulates isoform nox4 and increases the levels of Rac1 protein, a known regulator of both isoforms Nox1 and Nox2, in a transforming growth factor-beta receptor I-dependent manner and mediates activation of the nuclear factor-kappaB pathway. The inhibitors diphenyleneiodonium and apocynin, and SB431542, an inhibitor of the transforming growth factor-beta receptor I, block up-regulation of epidermal growth factor receptor ligands and Akt activation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | blocks up-regulation of epidermal growth factor receptor ligands and Akt activation by transforming growth factor-beta | Rattus norvegicus | |
diphenyleneiodonium | blocks up-regulation of epidermal growth factor receptor ligands and Akt activation by transforming growth factor-beta | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | fetal hepatocyte | Rattus norvegicus | - |