Activating Compound | Comment | Organism | Structure |
---|---|---|---|
HIV regulatory protein Tat | NADPH oxidase mediates Tat-induced superoxide release in microglia and macrophages | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | application of HIV regulatory protein Tat to microglia or macrophages causes dose- and time-dependent increases in superoxide formation that are prevented by both pharmacologic NADPH oxidase inhibitors and by specific decoy peptides gp91ds. Inhibition of NADPH oxidase attenuates Tat-induced release of IL-6 and TNFalpha, and MCP-1, and decreases microglial-mediated neurotoxicity. Macrophages derived from NADPH oxidase deficient mice display reduced superoxide production, released lower levels of cytokines/chemokines, and induce less neurotoxicity in response to Tat compared to wild-type macrophages | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | macrophages derived from NADPH oxidase deficient mice display reduced superoxide production, released lower levels of cytokines/chemokines, and induce less neurotoxicity in response to HIV regulatory protein Tat compared to wild-type macrophages | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gp91ds | fusion peptide that inhibits assembly of NADPH oxidase by mimicking the gp91phox docking site for the cytoplasmic p47phox subunit. gp91ds prevents NADPH oxidase activity, cytokine release, and neurotoxicity induced by HIV regulatory protein Tat in primary microglia | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
N9 cell | microglial cell | Mus musculus | - |