Literature summary for 1.6.3.1 extracted from

Abdala-Valencia, H.; Earwood, J.; Bansal, S.; Jansen, M.; Babcock, G.; Garvy, B.; Wills-Karp, M.; Cook-Mills, J.M.
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma (2007), Am. J. Physiol. Lung Cell. Mol. Physiol., 292, L1111-L1125.

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Application

Application	Comment	Organism
medicine	vascular cell adhesion molecule-1 induction of NADPH oxidase in the endothelium is necessary for the eosinophil recruitment during allergic inflammation	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	mice deficient in NADPH oxidase subunit gp91phox, CYBB mice, are irradiated and receive wild-type hematopoietic cells to generate chimeric CYBB mice. In response to ovalbumin challenge, the chimeric CYBB mice have increased numbers of eosinophils bound to the endothelium as well as reduced eosinophilia in the lung tissue and bronchoalveolar lavage. Ovalbumin-challenged chimeric CYBB mice have reduced airway hyperresponsiveness that can be restored by bypassing the endothelium with intratracheal administration of eosinophils	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)