D484T |
mutant of the alpha-helical loop of isoform Nox2, neither NADPH oxidase nor iodonitrotetrazolium reductase activity |
Homo sapiens |
D500A |
mutant of the alpha-helical loop of isoform Nox2, neither NADPH oxidase nor iodonitrotetrazolium reductase activity |
Homo sapiens |
D500G |
mutant of the alpha-helical loop of isoform Nox2, neither NADPH oxidase nor iodonitrotetrazolium reductase activity |
Homo sapiens |
D500R |
mutant of the alpha-helical loop of isoform Nox2, neither NADPH oxidase nor iodonitrotetrazolium reductase activity |
Homo sapiens |
K195A |
mutation in D-loop of isoform Nox2, complete loss of enzymic activity, but normal p47phox translocation and normal iodonitrotetrazolium reductase activity |
Homo sapiens |
K195E |
mutation in D-loop of isoform Nox2, complete loss of enzymic activity, but normal p47phox translocation and normal iodonitrotetrazolium reductase activity |
Homo sapiens |
additional information |
replacement of D-loop of isoform Nox2 with the homolog of Nox1, Nox3, or Nox4 is fully functional. Formylmethionine-activated mutant D-loopNox4 in Nox2 shows 4- to 8fold higher activity than wild-type |
Homo sapiens |
R198A/R198A |
mutation in D-loop of isoform Nox2, complete loss of enzymic activity, but normal p47phox translocation and normal iodonitrotetrazolium reductase activity |
Homo sapiens |
R198Q/R199Q |
mutation in D-loop of isoform Nox2, complete loss of enzymic activity, but normal p47phox translocation and normal iodonitrotetrazolium reductase activity |
Homo sapiens |
R199E |
mutation in D-loop of isoform Nox2, complete loss of enzymic activity, but normal p47phox translocation and normal iodonitrotetrazolium reductase activity |
Homo sapiens |
R199Q |
mutation in D-loop of isoform Nox2. Formylmethionine-activated mutant shows 4- to 8fold higher activity than wild-type |
Homo sapiens |