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Literature summary for 1.6.3.1 extracted from

  • De Deken, X.; Wang, D.; Many, M.C.; Costagliola, S.; Libert, F.; Vassart, G.; Dumont, J.E.; Miot, F.
    Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family (2000), J. Biol. Chem., 275, 23227-23233.
    View publication on PubMed
Search for more literature for 1.6.3.1

Activating Compound

Activating Compound Comment Organism Structure
additional information upregulated by agents activationg cAMP pathway Sus scrofa
additional information upregulated by agents activationg cAMP pathway Canis lupus familiaris

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
 Sus scrofa 16324
-
apical plasma membrane
-
 Canis lupus familiaris 16324
-
apical plasma membrane seven transmembrane regions found Homo sapiens 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for full activity Sus scrofa
Ca2+ required for full activity Canis lupus familiaris
Ca2+ required for full activity Homo sapiens
Ca2+ regulates enzyme activity Sus scrofa
Ca2+ regulates enzyme activity Canis lupus familiaris
Ca2+ regulates enzyme activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
177000
-
 calculated from DNA sequence Sus scrofa
180000
-
 SDS-PAGE Sus scrofa
180000
-
 SDS-PAGE Canis lupus familiaris
180000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Caenorhabditis elegans
-
 NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Canis lupus familiaris production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans O61213 high sequence similarities to mammalian proteins
-
Canis lupus familiaris
-
-
-
Homo sapiens Q9NRD8
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information
-
 Homo sapiens
-
additional information different tissues screened for ThOX2, except for a weak signal in stomach ThOX2 in exclusively found in thyroid cells Canis lupus familiaris
-
stomach very weak signal Canis lupus familiaris
-
thyroid gland
-
 Sus scrofa
-
thyroid gland
-
 Canis lupus familiaris
-
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Canis lupus familiaris NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Caenorhabditis elegans NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Canis lupus familiaris NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Sus scrofa
FAD binding site Homo sapiens