Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | enhances expression of protein | Canis lupus familiaris |
Cloned (Comment) | Organism |
---|---|
Cos-7, CHO, Hek293, NIH3T3, HeLa and PLB-XCGD cells transfected with ThOX2 DNA, protein is expressed but is exclusively found in cytoplasm and shows no activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenylene iodonium | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apical plasma membrane | - |
Rattus norvegicus | 16324 | - |
apical plasma membrane | - |
Canis lupus familiaris | 16324 | - |
apical plasma membrane | minor part of protein is expressed at cell surface, not found at surface of transfected CHO and PLB-XCGD cells | Homo sapiens | 16324 | - |
cytoplasm | major part of protein | Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | regulates enzyme activity | Homo sapiens | |
Ca2+ | regulates enzyme activity | Rattus norvegicus | |
Ca2+ | regulates enzyme activity | Canis lupus familiaris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
SDS-PAGE, deglycosylated form | Homo sapiens |
180000 | - |
SDS-PAGE, protein from transfected cells | Homo sapiens |
190000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD(P)H + H+ + O2 | Homo sapiens | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | Rattus norvegicus | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | Canis lupus familiaris | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | NAD(P)+ + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
cell line PC C-13 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | 5 N-glycosylation sites | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid gland | - |
Rattus norvegicus | - |
thyroid gland | follicular cells | Homo sapiens | - |
thyroid gland | follicular cells | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD(P)H + H+ + O2 | - |
Homo sapiens | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | - |
Rattus norvegicus | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | - |
Canis lupus familiaris | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | Homo sapiens | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | Rattus norvegicus | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | Canis lupus familiaris | NAD(P)+ + H2O2 | - |
? |