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Literature summary for 1.6.3.1 extracted from

  • Capuozzo, E.; Crifo, C.; Salerno, C.
    Polyene antibiotics inhibit superoxide-producing NADPH oxidase in a polymorphonuclear cell-free system (1993), Biochem. Pharmacol., 45, 766-768.
    View publication on PubMed
Search for more literature for 1.6.3.1

Activating Compound

Activating Compound Comment Organism Structure
arachidonic acid maximal enzyme activity in the presence of 0.25-0.35 mM, inhibition above Bos taurus
GTP-gammaS optimal concentration approx. 0.015 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
lucensomycin 0.02 mM, 50% inhibition Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bos taurus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + O2 Bos taurus
-
 NADP+ + O2-
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 multienzyme complex
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil resting neutrophils Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.015
-
 activity in membranes after 1 h at 25°C Bos taurus
0.033
-
 activity in freshly prepared membranes at 25°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + O2
-
 Bos taurus NADP+ + O2-
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
 activity in membranes, approx. 50% activity are lost after 1 h, freeze/thawing accelerates inactivation, loss of 90% activity after 1 h Bos taurus