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Literature summary for 1.6.2.4 extracted from

  • Kuzu, M.; Ciftci, M.
    Purification and characterization of NADPH-cytochrome P450 reductase from lake van fish liver microsomes and investigation of some chemical and metals effects on the enzyme activity (2015), Turk. J. Chem., 39, 149-158 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Ag+ competitive inhibition Alburnus tarichi
Cu2+ competitive inhibition Alburnus tarichi
Hg2+ competitive inhibition Alburnus tarichi
additional information benzalkonium chloride and acriavine do not show any effect on enzyme activity Alburnus tarichi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005208
-
NADPH at pH 8.0 and 50°C Alburnus tarichi
0.01282
-
ferricytochrome c at pH 8.0 and 50°C Alburnus tarichi

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Alburnus tarichi
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
As5+ activates Alburnus tarichi
Ca2+ activates Alburnus tarichi
Co2+ activates Alburnus tarichi
Mn2+ activates Alburnus tarichi
additional information Pb2+ , Fe3+ , Ni2+ , Cd2+ , Zn2+ , and Tl+ do not have any effect on enzyme activity Alburnus tarichi

Organism

Organism UniProt Comment Textmining
Alburnus tarichi
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose column chromatography Alburnus tarichi

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Alburnus tarichi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + ferricytochrome c
-
Alburnus tarichi NADP+ + ferrocytochrome c
-
?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Alburnus tarichi

Synonyms

Synonyms Comment Organism
CPR
-
Alburnus tarichi
cytochrome P450 reductase
-
Alburnus tarichi

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
Alburnus tarichi

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
7.6
-
the enzyme remains stable at pH 7.6 after 24 h Alburnus tarichi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Alburnus tarichi

Cofactor

Cofactor Comment Organism Structure
FAD
-
Alburnus tarichi
FMN
-
Alburnus tarichi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00136
-
Hg2+ at pH 8.0 and 50°C Alburnus tarichi
0.0016
-
Ag+ at pH 8.0 and 50°C Alburnus tarichi
0.27979
-
Cu2+ at pH 8.0 and 50°C Alburnus tarichi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0021936
-
at pH 8.0 and 50°C Alburnus tarichi Hg2+
0.0029877
-
at pH 8.0 and 50°C Alburnus tarichi Ag+
0.39766
-
at pH 8.0 and 50°C Alburnus tarichi Cu2+