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BRENDA support

Literature summary for 1.6.2.4 extracted from

  • Kranendonk, M.; Marohnic, C.C.; Panda, S.P.; Duarte, M.P.; Oliveira, J.S.; Masters, B.S.; Rueff, J.
    Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase (2008), Arch. Biochem. Biophys., 475, 93-99.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
V492E mutation causes Antley-Bixler syndrome due to diminished binding of the FAD cofactor. Activity is restored by the addition of FAD Homo sapiens
Y459H mutation causes Antley-Bixler syndrome due to diminished binding of the FAD cofactor. Activity is restored by the addition of FAD Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
CYPOR
-
Homo sapiens
cytochrome P450 reductase
-
Homo sapiens