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Literature summary for 1.6.2.4 extracted from

  • Venkateswarlu, K.; Lamb, D.C.; Kelly, D.E.; Manning, N.J.; Kelly, S.L.
    The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in steril biosynthesis or in reconstitution of CYP activity (1998), J. Biol. Chem., 273, 4492-4496.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in transformed strains Saccharomyces cerevisiae
expression in transformed strains of Saccharomyces cerevisiae Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol heterologously expressed native and truncated protein Homo sapiens 5829
-
cytosol heterologously expressed native and truncated protein Saccharomyces cerevisiae 5829
-
microsome heterologously expressed native and truncated protein Homo sapiens
-
-
microsome heterologously expressed native and truncated protein Saccharomyces cerevisiae
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
truncated protein Saccharomyces cerevisiae
78000
-
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae involved in the sterol biosynthesis pathways ?
-
?
additional information Saccharomyces cerevisiae JL20 involved in the sterol biosynthesis pathways ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
JL20 strain
-
Saccharomyces cerevisiae JL20
-
JL20 strain
-

Renatured (Commentary)

Renatured (Comment) Organism
native or truncated protein reconstituts ergosterol biosynthesis when added to a cell-free system, as well as reconstitution of activity with purified Saccharomyces cerevisiae CYP61, sterol 22-desaturase, Candida albicans and human CYP51 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
24.3
-
purified truncated protein Saccharomyces cerevisiae
36
-
purified truncated protein Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in the sterol biosynthesis pathways Saccharomyces cerevisiae ?
-
?
additional information involved in the sterol biosynthesis pathways Saccharomyces cerevisiae JL20 ?
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Saccharomyces cerevisiae