Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.2.2 extracted from

  • Rahaman, M.M.; Nguyen, A.T.; Miller, M.P.; Hahn, S.A.; Sparacino-Watkins, C.; Jobbagy, S.; Carew, N.T.; Cantu-Medellin, N.; Wood, K.C.; Baty, C.J.; Schopfer, F.J.; Kelley, E.E.; Gladwin, M.T.; Martin, E.; Straub, A.C.
    Cytochrome b5 reductase 3 modulates soluble guanylate cyclase redox state and cGMP signaling (2017), Circ. Res., 121, 137-148 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
ZINC39395747
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + ferricytochrome b5 + oxidized soluble guanylate cyclase Rattus norvegicus
-
 NAD+ + H+ + ferrocytochrome b5 + reduced soluble guanylate cyclase
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ferricytochrome b5 + oxidized soluble guanylate cyclase
-
 Rattus norvegicus NAD+ + H+ + ferrocytochrome b5 + reduced soluble guanylate cyclase
-
 ?

Subunits

Subunits Comment Organism
? x * 34000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
CYB5R3
-
 Rattus norvegicus
cytochrome b5 reductase 3
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function cytochrome b5 reductase 3 expression and activity is critical for nitric oxide-stimulated cGMP production and vasodilation Rattus norvegicus