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Literature summary for 1.6.2.2 extracted from

  • Ming, H.; Lan, Y.; He, F.; Xiao, X.; Zhou, X.; Zhang, Z.; Li, P.; Huang, G.
    Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis (2015), Chin. J. Cancer, 34, 459-467 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + ferricytochrome b5 Homo sapiens
-
NAD+ + H+ + ferrocytochrome b5
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CNE-2 cell
-
Homo sapiens
-
HONE-1 cell
-
Homo sapiens
-
nasopharyngeal carcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ferricytochrome b5
-
Homo sapiens NAD+ + H+ + ferrocytochrome b5
-
?

Synonyms

Synonyms Comment Organism
CYB5R2
-
Homo sapiens
cytochrome b5 reductase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme up-regulates the expression of genes that negatively modulate angiogenesis in nasopharyngeal carcinoma cells and down-regulates the expression of vascular endothelial growth factor to reduce angiogenesis, thereby suppressing tumor formation Homo sapiens