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BRENDA support

Literature summary for 1.6.2.2 extracted from

  • Barham, H.M.; Inglis, R.; Chinje, E.C.; Stratford, I.J.
    Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells (1996), Br. J. Cancer, 74, 1188-1193.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine potentially an important enzyme required for the reductive activation of bioreductive drugs that can be used in the treatment of solid tumours Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
different cancer cell lines
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.036 0.109 activity in lysates of different cancer cell lines Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome b5 + NADH artificial electron acceptor in the presence of menadione: cytochrome c Homo sapiens 2 ferrocytochrome b5 + NAD+ + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
reduction of cytochrome c Homo sapiens