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Literature summary for 1.6.1.2 extracted from

  • Gameiro, P.A.; Laviolette, L.A.; Kelleher, J.K.; Iliopoulos, O.; Stephanopoulos, G.
    Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle (2013), J. Biol. Chem., 288, 12967-12977 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + NAD+ Homo sapiens
-
 NADP+ + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
786-O cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
renal carcinoma cell
-
 Homo sapiens
-
SK-MEL-5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + NAD+
-
 Homo sapiens NADP+ + NADH
-
 ?

Synonyms

Synonyms Comment Organism
nicotinamide nucleotide transhydrogenase
-
 Homo sapiens
NNT
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown decreases reductive carboxylation and stimulates glucose catabolism in the tricarboxylic acid cycle Homo sapiens
metabolism the enzyme coordinates glutamine and glucose metabolism in the tricarboxylic acid cycle Homo sapiens