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Literature summary for 1.6.1.2 extracted from
- Energy-linked nicotinamide nucleotide transhydrogenase. Kinetics and regulation of purified and reconstituted transhydrogenase from beef heart mitochondria (1982), J. Biol. Chem., 257, 14760-14766.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-AMP | noncompetitive vs. NAD+, competitive vs. NADPH | Bos taurus |  |
| 5'-AMP | competitive vs. NAD+, noncompetitive vs. NADPH | Bos taurus | |
| cardiolipin | noncompetitive vs. NAD+ and NADPH | Bos taurus | |
| NADH | competitive vs. NAD+, noncompetitive vs. NADPH | Bos taurus | |
| NADP+ | noncompetitive vs. NAD+, competitive vs. NADPH | Bos taurus | |
| palmitoyl-CoA | competitive inhibition vs. NADPH | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0017 | - |
NADP+ | cosubstrate NADH | Bos taurus | |
| 0.01 | - |
NADH | cosubstrate NADP+ | Bos taurus | |
| 0.02 | - |
NADPH | cosubstrate NAD+ | Bos taurus | |
| 0.029 | - |
NADPH | + acetylpyridine adenine dinucleotide | Bos taurus | |
| 0.125 | - |
NAD+ | cosubstrate NADPH | Bos taurus | |
| 0.166 | - |
acetylpyridine adenine dinucleotide | cosubstrate NADPH | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Bos taurus | 31966 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| NADPH + NAD+ = NADP+ + NADH | proposed proton-pump mechanism | Bos taurus |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| reconstitution into liposomes | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + NADP+ | the reaction is coupled to a transmembrane proton translocation from cytosol to mitochondria | Bos taurus | NAD+ + NADPH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
| NADH | - |
Bos taurus | |
| NADP+ | - |
Bos taurus | |
| NADPH | - |
Bos taurus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
palmitoyl-CoA | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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