Literature summary for 1.6.1.2 extracted from

Phelps, D.C.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: active site modification by 5-[p-(fluorosulfonyl)benzoyl]adenosine (1985), Biochemistry, 24, 3503-3507.

Search for more literature for 1.6.1.2

Inhibitors

Inhibitors	Comment	Organism	Structure
5'-[p-(fluorosulfonyl)benzoyl]-adenosine	structural analog of adenosine, 2 mM, almost complete inactivation after 25 min, acetylpyridine adenine dinucleotide, NADP+, 5'-AMP, 5'-ADP or a mixture of 2'-AMP and 3'-AMP protect from inactivation, NADPH accelerates the inhibition rate, inhibition rate constant increases 50fold by increasing the pH from 6.0 to 8.5	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial membrane	-	Bos taurus	31966	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Bos taurus	-

Cofactor

Cofactor	Comment	Organism	Structure
additional information	no flavin cofactor, differentiation from EC 1.6.1.1.	Bos taurus
NAD+	-	Bos taurus
NADH	-	Bos taurus
NADP+	-	Bos taurus
NADPH	-	Bos taurus

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Release 2023.1 (January 2023)