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Literature summary for 1.6.1.2 extracted from
- Mitochondrial nicotinamide nucleotide transhydrogenase: nonidentical modification by N,N-dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline at the NAD(H) binding site (1985), Arch. Biochem. Biophys., 243, 298-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N,N'-Dicylclohexylcarbodiimide | NADH, acetylpyridine adenine dinucleotide, 5'-AMP and 5'-ADP offer nearly complete protection | Bos taurus |  |
| N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.6 | - |
NMNH | reduction of thio-NADP+ in energized submitochondrial particles | Bos taurus | |
| 3.4 | - |
NMNH | reduction of thio-NADP+ in non energized submitochondrial particles | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Bos taurus | 31966 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NMNH + thio-NADP+ | - |
Bos taurus | NMN + thio-NADPH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
| NADH | - |
Bos taurus | |
| NADP+ | - |
Bos taurus | |
| NADPH | - |
Bos taurus | |
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