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Literature summary for 1.5.8.4 extracted from

  • Liu, G.; Hou, G.; Li, L.; Li, Y.; Zhou, W.; Liu, L.
    Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo (2016), Oncotarget, 7, 32607-32616 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.8.4

Application

Application Comment Organism
diagnostics the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis Homo sapiens
medicine expression of DMGDH is decreased in hepatocellular carcinoma. the enzyme can be applied as valuable biomarker for both diagnosis and prognosis Homo sapiens
medicine the enzyme is biomarker for both diagnosis and prognosis for hepatocellular carcinoma Homo sapiens
medicine the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N-dimethylglycine + electron-transfer flavoprotein + H2O Homo sapiens
-
 sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9UI17
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell hepatocellular carcinoma Homo sapiens
-
hepatocellular carcinoma cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
LM3 cell
-
 Homo sapiens
-
SMMC-7721 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
-
 Homo sapiens sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Synonyms

Synonyms Comment Organism
DMGDH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is decreased in hepatocellular carcinoma down
Homo sapiens expression is decreased in hepatocellular carcinoma down

General Information

General Information Comment Organism
metabolism the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed Homo sapiens
physiological function dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway Homo sapiens
physiological function DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed Homo sapiens
physiological function the enzyme suppresses metastasis in hepatocellular carcinoma Homo sapiens