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Literature summary for 1.5.8.4 extracted from
- Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics (1981), J. Biol. Chem., 256, 4102-4108.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
x * 90000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? |  |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | reaction of the choline degradation pathway | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N,N-dimethylglycine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | sarcosine + formaldehyde + reduced acceptor | - |
? | |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | reaction of the choline degradation pathway | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 90000, SDS-PAGE | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | covalently bound | Rattus norvegicus | |
| Tetrahydropteroylpentaglutamate | - |
Rattus norvegicus | |
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