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Literature summary for 1.5.8.4 extracted from

  • Wittwer, A.J.; Wagner, C.
    Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins (1981), J. Biol. Chem., 256, 4109-4115.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Dimethylthetin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epsilon-N-methyl-L-lysine + acceptor + H2O
-
 Rattus norvegicus formaldehyde + L-lysine + reduced acceptor
-
 ?
N,N-dimethylglycine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
 ?
N,N-dimethylglycine + acceptor + H2O bound tetrahydrofolate interacts directly with the enzyme and serves as an acceptor for the one-carbon unit produced during the oxidative demethylation of dimethylglycine Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
 ?
N-methyl-L-alanine + acceptor + H2O
-
 Rattus norvegicus formaldehyde + L-alanine + reduced acceptor
-
 ?
sarcosine + acceptor + H2O
-
 Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD covalently bound Rattus norvegicus