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Literature summary for 1.5.8.4 extracted from
- Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver (1985), Arch. Biochem. Biophys., 243, 396-407.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Methoxyacetate | competitive inhibitor at low substrate concentrations | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
dimethylglycine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | reaction of the choline degradation pathway | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.268 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N,N-dimethylglycine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | sarcosine + formaldehyde + reduced acceptor | - |
? | |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
| N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | reaction of the choline degradation pathway | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
N,N-dimethylglycine | - |
Rattus norvegicus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | covalently bound | Rattus norvegicus | |
| Tetrahydropteroylpentaglutamate | - |
Rattus norvegicus | |
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